Hydroxymethylation of active methenyl compounds: DMSO as methylene source and H2O as oxygen source

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2022-03-16 DOI:10.1016/j.tetlet.2022.153663

Liang Zhang, Shuhua Liu, Yunliang Lin, Yuliang Wang

引用次数: 5

Abstract

A mild and efficient method for hydroxymethylation of active methenyl compounds has been described. In this transformation, the widely available solvents DMSO and H₂O served as methylene and oxygen sources, respectively. Under promotion of activator and base, the reaction could be used for the construction of a series of α-hydroxymethylated carbonyl compounds with all-carbon quaternary carbon center in good to excellent yield.

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活性甲基化合物的羟甲基化:DMSO为亚甲基源，H2O为氧源

介绍了一种温和而有效的活性甲基化合物羟甲基化方法。在这个转化过程中，广泛使用的溶剂DMSO和H2O分别作为亚甲基和氧源。在活化剂和碱的促进下，该反应可用于构建一系列具有全碳季碳中心的α-羟基甲基化羰基化合物，收率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.