Poly (vinyl alcohol)/chitosan/polyethylene glycol-assembled graphene oxide bio-nanocomposites as a prosperous candidate for biomedical applications and drug/food packaging industry

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2022-03-15 DOI:10.1016/j.ijbiomac.2022.01.086

Saeid Mohammadi, Amir Babaei

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引用次数: 20

Abstract

The graphene oxide (GO) nanoplates and polyethylene glycol-decorated GO (GO-PEG nano-hybrid) were synthesized and characterized by FTIR, Raman, XRD, AFM, FE-SEM-EDAX and MTT assay. Obtained results confirmed the graphite oxidation and also assembly of PEG upon GO plates. The MTT assay indicated that GO-PEG nanohybrid enhanced biocompatibility to cells compared to the GO. The GO-PEG nanohybrid was introduced to the polyvinyl alcohol/chitosan carbohydrate (PVA/CS) blends. The bio-nanocomposite were prepared by simple casting method. The GO-PEG nanohybrids demonstrated a significant role in improving thermal, mechanical and antibacterial properties. Accordingly, bio-nanocomposites containing modified GO (PVA/CS/GO-PEG) exhibited higher glass transition temperature (Tg), Young's modulus, tensile strength, elongation at break and antibacterial properties than nanocomposites containing pure GO (PVA/CS/GO). The biodegradation outcomes indicated that the highest weight loss and degradability is related to the bio-nanocomposite containing modified GO (PVA/CS/GO-PEG), which was also confirmed by FE-SEM micrographs. Therefore, PVA/CS/GO-PEG bio-nanocomposites can be a suitable candidate for biomedical applications (tissue engineering, wound dressing) and food-drug packaging industry.

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聚乙烯醇/壳聚糖/聚乙二醇组装氧化石墨烯生物纳米复合材料是生物医学应用和药品/食品包装行业的一个繁荣的候选材料

合成了氧化石墨烯(GO)纳米板和聚乙二醇修饰的氧化石墨烯(GO- peg)纳米杂化物，并通过FTIR、拉曼光谱、XRD、AFM、FE-SEM-EDAX和MTT分析对其进行了表征。得到的结果证实了石墨氧化和聚乙二醇在氧化石墨烯板上的组装。MTT实验表明，与氧化石墨烯相比，氧化石墨烯-聚乙二醇纳米杂化物增强了细胞的生物相容性。将GO-PEG纳米杂化物引入聚乙烯醇/壳聚糖(PVA/CS)共混物中。采用简单铸造法制备了生物纳米复合材料。GO-PEG纳米杂化材料在提高热、机械和抗菌性能方面发挥了重要作用。因此，含有改性氧化石墨烯(PVA/CS/GO- peg)的生物纳米复合材料比含有纯氧化石墨烯(PVA/CS/GO)的纳米复合材料具有更高的玻璃化转变温度(Tg)、杨氏模量、拉伸强度、断裂伸长率和抗菌性能。生物降解结果表明，含改性氧化石墨烯(PVA/CS/GO- peg)的生物纳米复合材料的失重率和可降解性最高，这一点也得到了FE-SEM显微照片的证实。因此，PVA/CS/GO-PEG生物纳米复合材料可以成为生物医学应用(组织工程，伤口敷料)和食品药品包装行业的合适候选人。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.