Determination of glucose-6-phosphate dehydrogenase levels in red cell preparations.

Abstract

Data are presented which prove that accurate measurement of glucose-6-phosphate dehydrogenase (G6PD) activity in red cells can be affected by the presence of leukocytes and platelets. Measurement of the enzyme in red cell preparations (after buffy coat removal) permits more accurate identification of patients with deficient enzyme activity, especially in the presence of anemia and/or leukocytosis.