Effect of the Ca2+ chelators EDTA and EGTA on sinoatrial-node activity and heart irritability.

F Solti, S Juhász-Nagy, V Kecskeméti, B Czakó, V Németh, V Kékesi
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Abstract

The effect of the Ca-chelators EDTA and EGTA on sinoatrial activity and heart irritability was studied in dog experiments by perfusing the artery supplying the sinoatrial node. Beside the usual ECG recordings left and right atrial and left and right ventricular epicardial electrograms, His-bundle electrogram and the early activity of the sinoatrial node were recorded. In addition action potentials were recorded from the left auricle and right ventricle of the dog hearts. Local application around the sinoatrial and atrio-ventricular nodes of EDTA and EGTA caused sinus bradycardia and later sinus arrest within 1 min after introduction of the drugs. For substitution of the sinus rhythm junctional (seldom lower atrial) escape rhythm developed. One to two minutes later it was followed by atrial premature beats and even later atrial flutter and fibrillation could be recorded. In one third of the cases atrial fibrillation was followed by secondary ventricular fibrillation. Atrio-ventricular impulse conduction was prolonged in the av node by EDTA and EGTA. Atrial action potentials and the slow (Ca dependent) ventricular action potentials were depressed by EDTA and EGTA.

Ca2+螯合剂EDTA和EGTA对窦房结活动和心脏激惹的影响。
通过灌注窦房结供血动脉的方法,研究了钙螯合剂EDTA和EGTA对窦房活动和心脏激激性的影响。除常规心电图记录左、右心房、左、右心室心外膜电图外,记录his束电图及窦房结早期活动。此外,还记录了左耳廓和右心室的动作电位。EDTA和EGTA局部应用于窦房结和房室结周围,用药后1 min内引起窦性心动过缓和窦性骤停。为取代窦性心律,形成了连接性心律(很少出现下心房心律)。1 ~ 2分钟后出现心房早搏,甚至更晚出现心房扑动和心房颤动。三分之一的房颤患者继发室性颤动。EDTA和EGTA使房室结的房室脉冲传导延长。EDTA和EGTA抑制心房动作电位和慢速(钙依赖性)心室动作电位。
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