[The effect of biseptol and sodium salicylate administration on the concentration of serotonin and histamine and mono- and diamine oxidase activities in rat placenta].

Abstract

It is known that two biogenic amines:serotonin and histamine, as well as the enzymes connected with their metabolism (mono- and diamine oxidase), play very important role in human and animal fetal development. We have investigated the effect of Biseptol and sodium salicylate administered to pregnant rats on the concentrations of serotonin and histamine and activities of the above mentioned enzymes in placenta. The obtained results showed that the administration of Biseptol has no influence on the serotonin concentration, whereas the administration of sodium salicylate caused slight increase of serotonin concentration in rat placenta. The activity of monoamine oxidase was elevated after administration of both drugs (Tabl. I, Fig. 1). The administration of Biseptol decreased the histamine concentration and caused the marked increase of DAO activity. The sodium salicylate administration to the pregnant rats didn't influence on the histamine concentration, whereas it caused parallel twofold increase of DAO activity (Tabl. II, Fig. 2).