Striatal dopamine levels after unilateral lesions of the substantia nigra: evidence for a contralateral decrease.

Abstract

Unilateral electrolytical and chemical (6-hydroxydopamine) lesions in the substantia nigra (SN) of rats were followed 7 days later by considerable bilateral decreases of neostriatal dopamine (DA) levels. Similarly, the DA content of the substantia nigra decreased not only ipsilaterally but contralaterally as well. Positive correlations were found between ipsi- and contralateral nigral DA levels, ipsi- and contralateral striatal DA and between the DA level of the SN and the striatum of the corresponding side both ipsi- and contralaterally to the lesion.