Gonadoliberin (LHRH) mediated release of choriogonadotropin in experimental human and animal tumors in vitro.

Abstract

Luteinizing hormone-releasing hormone (LHRH) stimulates a rapid release of chorionic gonadotropin (CG) in vitro from cell cultures of the JEG-3 choriocarcinoma and the R3230AC experimental rat mammary adenocarcinoma. The release of CG is time dependent: and dose-related. The addition of insulin or thyrotropin releasing hormone (TRH) to the cell cultures does not alter basal CG production.