Modification of the cytoprotective effect of prostacyclin on gastric epithelial cells of rats by colchicine.

G Karácsony, G A Bálint, G Lukács, V Varró
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Abstract

The effect of prostacyclin (PGI2) and colchicine on fundic gastric mucosa of sexually mature female Wistar rats was investigated histochemically after restraint stress. Under PGI2 treatment the ulcer index decreased significantly; this effect was moderately inhibited by colchicine. The mucus content of epithelial cells was decreased during restraint and was increased by PGI2 treatment. This protective action was also inhibited by colchicine. The nuclear volume of fundic epithelial cells increased significantly in restraint and decreased following colchicine application. These phenomena were not influenced by PGI2. According to our results the cytoprotective effect of PGI2 is not accompanied by nuclear volume changes.

秋水仙碱修饰前列环素对大鼠胃上皮细胞的细胞保护作用。
采用组织化学方法研究了前列腺环素(PGI2)和秋水仙碱对性成熟雌性Wistar大鼠胃底黏膜的影响。PGI2治疗组溃疡指数明显降低;秋水仙碱可适度抑制这种作用。抑制时上皮细胞黏液含量降低,PGI2处理后黏液含量升高。秋水仙碱也抑制了这种保护作用。基底上皮细胞的核体积在抑制下显著增加,秋水仙碱作用后减少。这些现象不受PGI2的影响。根据我们的研究结果,PGI2的细胞保护作用不伴随着核体积的变化。
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