Different effects of oral glycine and methionine on urinary lithogenic substances.

Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01

W Tschöpe, E Ritz, H Schmidt-Gayk, L Knebel

引用次数: 0

Abstract

Nine male healthy volunteers were examined during a control period, during an oral glycine load (45 g/day, 600 mmol) and oral methionine (6 g/day, 40 mmol). Glycine caused a significant increase of urinary oxalate above baseline (from 644 to 797 mumol/day) without change in calciuria (4.74 vs 4.84 mmol/day). In contrast methionine caused no change of oxaluria, but a significant increase in calciuria (from 4.74 to 6.9 mmol/day). Alterations of lithogenic ions in urine after protein ingestion are mediated by different amino acids. The particular lithogenic risk of animal protein may be related to its high methionine/cystine and glycine content.

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口服甘氨酸和蛋氨酸对尿结石物质的不同影响。

9名男性健康志愿者在对照期接受检查，分别是口服甘氨酸(45 g/天，600 mmol)和蛋氨酸(6 g/天，40 mmol)。甘氨酸导致尿草酸显著高于基线(从644 mmol/天增加到797 mmol/天)，而钙尿量没有变化(4.74 mmol/天vs 4.84 mmol/天)。相比之下，蛋氨酸没有引起草酸尿的变化，但钙尿显著增加(从4.74到6.9 mmol/天)。蛋白质摄入后尿中产石离子的改变是由不同的氨基酸介导的。动物蛋白的特殊致石风险可能与其高蛋氨酸/胱氨酸和甘氨酸含量有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association

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