M Urcia, M C Leal, L Lafarga, V Guillén, J Hergueta, F R Pérez-López
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引用次数: 0
Abstract
Wistar rats bearing N-nitrosomethylurea-induced mammary tumors received intratumoral injections of prospidium chloride or saline. Each tumor with 30-100 mm2 (the product of the two largest perpendicular diameters) received 20 mg of prospidium chloride diluted in 100 microliter of saline, and increasing amounts of 20 mg of the product in the same volume for every additional 100 mm2 or fraction of tumor. After a week the treatment was repeated in the same way. Control rats received only saline without prospidium chloride. No significant differences were observed regarding the tumor area, total tumor area/rat, and body weight when comparing the rats receiving prospidium chloride and the control rats. Prospidium chloride does not show any direct oncolytic effect upon the experimental model employed.
n -亚硝基甲基脲致乳腺肿瘤Wistar大鼠瘤内注射氯化钾或生理盐水。每一个30-100 mm2(两个最大垂直直径的乘积)的肿瘤接受20毫克氯化钾稀释在100微升生理盐水中，每增加100 mm2或肿瘤的一部分，以相同体积增加20毫克的产品。一周后，以同样的方式重复治疗。对照组大鼠只给予不含氯化钾的生理盐水。在肿瘤面积、肿瘤总面积/大鼠及体重方面，给予氯化亚锑的大鼠与对照组比较均无显著差异。对所采用的实验模型，氯化锑没有显示出任何直接的溶瘤作用。
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