ELSMOS — an extended least squares modelling system in FORTRAN IV for mini- or micro-computer implementation

Abstract

A new program ELSMOS has been developed for curve fitting of pharmacokinetic and pharmacodynamic data. The form is sufficiently general, with user-defined model in a separate FORTRAN subroutine, to permit application in many other areas. The principal features are the use of a user-defined error model for statistically rigorous automatic weighting of data, and the containment of program size to a level that enables mini- or micro-computer implementation.