Phencyclidine-like discriminative stimulus properties of the stereoisomers of dioxadrol.

Substance and alcohol actions/misuse Pub Date : 1984-01-01
B L Slifer, R L Balster
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Abstract

Rats (N=6) were trained to discriminate 3.0 mg/kg i.p. phencyclidine (PCP) from saline in a 2-lever fixed-ratio 32 operant discrimination procedure for food presentation. Generalization tests were conducted with other doses of PCP as well as with various doses of the stereoisomers of dioxadrol. Dose-dependent PCP-like discriminative stimulus effects were obtained with dexoxadrol but not with levoxadrol, however overall rates of responding were decreased to a comparable extent by 30 mg/kg of both compounds. PCP was 3.6 times more potent than dexoxadrol in producing stimulus control of responding. These data provide some evidence for stereoselectivity of action for dioxadrol, however nonPCP-like effects of levoxadrol are present at doses only 3 times greater than those doses of dexoxadrol that result in PCP-lever responding. Therefore, absolute stereospecificity beyond 3-fold cannot be demonstrated by these data.

二恶二醇立体异构体的类苯环利定判别刺激性质。
6只大鼠采用二水平固定比32操作鉴别方法,训练其区分3.0 mg/kg剂量苯环利定(PCP)和生理盐水。对其他剂量的PCP以及不同剂量的二恶二醇立体异构体进行了泛化试验。dexoxadrol获得了剂量依赖的pcp样判别刺激效应,而左旋沙德罗尔则没有,然而,两种化合物30 mg/kg的总体反应率降低了相当程度。PCP在产生刺激控制反应方面的效力是dexoxadrol的3.6倍。这些数据为二恶阿德罗的立体选择性作用提供了一些证据,然而,左旋沙德罗的非pcp样效应在剂量仅为导致pcp水平反应的右旋沙德罗剂量的3倍时存在。因此,这些数据不能证明绝对的立体特异性超过3倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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