An ultrastructural change in developing rat cerebral cortex: a morphometrical study.

Folia psychiatrica et neurologica japonica Pub Date : 1983-01-01 DOI:10.1111/j.1440-1819.1983.tb00347.x

K Tamai, K Ikari, M Hayashi

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引用次数: 2

Abstract

Five age groups, each composed of four animals from each of the following ages, were used to assess age-related ultrastructural changes with development in the neuropil of the III layer of the frontal cortex (area 6) in rats; 1, 2, 3, 5 and 12 weeks old. Random samplings within the neuropil were taken to produce 25 electron micrographs in each rat (totaling 500). The profiles of axon terminals, dendrites and mitochondria in each element in the neuropil of each micrograph were traced. The percentage of their areas for the area of neuropil (relative volume fraction) was examined using the image analyzer system. The size and number of synaptic terminals were counted. The relative volume fractions of both the axon terminals and mitochondria in the terminals for the neuropil were found to have increased in the mature rats. On the other hand, the relative volume fraction of dendrites for the neuropil had been unchanged and the size of the terminals had gradually decreased. The number of terminals had progressively increased with development.

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发育中的大鼠大脑皮层超微结构变化:形态计量学研究。

采用5个年龄组，每组4只动物，分别来自以下各年龄组，评估大鼠额叶皮质III层(6区)神经pil随年龄的发展而发生的超微结构变化;1、2、3、5和12周大。在神经膜内随机取样，每只大鼠获得25张电子显微图(共500张)。在每张显微照片上记录神经细胞中各元素的轴突终末、树突和线粒体的分布。使用图像分析系统检测其面积占神经瘤面积的百分比(相对体积分数)。计数突触末梢的大小和数量。成熟大鼠轴突终末和神经末梢线粒体的相对体积分数均增加。另一方面，神经元树突的相对体积分数没有变化，末梢的大小逐渐减小。终点站的数目随着发展而逐渐增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Folia psychiatrica et neurologica japonica

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