Amygdaloid kindling in Papio cynocephalus and subsequent recurrent spontaneous seizures.

Abstract

Three baboons, Papio cynocephalus, (two photosensitive and one nonphotosensitive) were subjected to amygdaloid kindling. Electroclinical profile of seizure development-developed seizure compares very favourably to that described in photosensitive baboons, Papio papio, with rapid seizure progression and ultimate emergence of Stage 5 bisymmetrical and bisynchronous generalized convulsive state. In addition, one baboon developed spontaneous recurrent seizures which were identical to the kindled Stage 5 seizure. It is concluded that the state of exceptional seizure susceptibility observed in Papio papio is shared by Papio cynocephalus, although photosensitivity and kindled generalized convulsion appear to be independent variables.