[Stimulation of immunoreactivity against endogenous retroviruses and protection against leukemia in aged AKR mice after vaccination with antibodies to viral surface components. The role of antibodies to p15(E)].

H Schwarz, H J Thiel, K J Weinhold, D P Bolognesi, W Schäfer
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Abstract

Antibody against viral gp71 is effective therapeutically for high leukemic AKR mice if injected immediately after birth. No corresponding effect could be observed after inoculation later in life when the endogenous virus burden is already high. However, if antibody treatment was supplemented by the injection of p15(E) antibody, a therapeutic effect was observed even in older mice first treated at an age of 21/2 months. Those mice produced antibodies against viral surface proteins and appeared to be able to survive longer than control mice. Thus p15(E) antibody might be able to overcome retroviral associated immuno-deficiency. This therapy may have implications for the treatment of the apparently retroviral induced acquired immunodeficiency syndrome (AIDS) of man.

接种病毒表面成分抗体后,刺激老年AKR小鼠对内源性逆转录病毒的免疫反应性和对白血病的保护作用。p15(E)抗体的作用[j]。
如果在出生后立即注射抗病毒gp71抗体,对高白血病AKR小鼠有效。当内源性病毒负担已经很高时,接种后未观察到相应的效果。然而,如果在抗体治疗的基础上补充注射p15(E)抗体,即使在2个半月大的老年小鼠中也能观察到治疗效果。这些小鼠产生了针对病毒表面蛋白的抗体,似乎比对照组小鼠存活的时间更长。因此p15(E)抗体可能能够克服逆转录病毒相关的免疫缺陷。这种疗法可能对治疗明显由逆转录病毒引起的人类获得性免疫缺陷综合征(艾滋病)有启示。
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