Studies on interactions between striatal dopaminergic and cholinergic mechanisms in the early abstinence after chronic treatment with barbital in the rat.

Substance and alcohol actions/misuse Pub Date : 1984-01-01
S A Persson, G Wahlström
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引用次数: 0

Abstract

Accumulation in the rat striatum of 3,4-dihydroxy-L-phenylalanine (DOPA) after inhibition of the neuronal decarboxylase was not significantly altered in the early abstinence after chronic treatment with barbital for 36-39 weeks in comparison with controls treated with water. Pilocarpine (10 mg/kg i.p.) increased the accumulation of DOPA in rats chronically treated with barbital and also in controls treated with water. Some weak correlations between striatal DOPA accumulation and changes in body weight or fluid consumption during the first three days of the abstinence were observed. There was also a highly significant, positive correlation (r = 0.85) between striatal DOPA accumulation and the number of convulsions in rats chronically treated with barbital and injected with NaCl. The corresponding correlation in rats chronically treated with barbital and injected with pilocarpine was positive but not significant (r = 0.50). No evidence for an increased sensitivity at muscarinic receptors in the striatum was found.

大鼠慢性巴比妥戒断早期纹状体多巴胺能与胆碱能相互作用机制的研究。
与用水处理的对照组相比,长期服用巴比比36-39周的早期戒断后,抑制神经元脱羧酶后大鼠纹状体中3,4-二羟基- l -苯丙氨酸(DOPA)的积累没有显著改变。匹罗卡品(10 mg/kg i.p.)增加了长期服用巴比妥的大鼠和用水处理的对照组的多巴积累。在戒断的前三天,纹状体多巴积累与体重或液体消耗的变化之间存在微弱的相关性。长期服用巴比妥和注射氯化钠的大鼠纹状体多巴积累与惊厥次数呈高度显著正相关(r = 0.85)。长期服用巴比妥和注射匹罗卡品的大鼠相应的相关性为正,但不显著(r = 0.50)。没有证据表明纹状体中毒蕈碱受体的敏感性增加。
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