HLA phenotypes and idiopathic nephrotic syndrome in children.

Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01

H Ruder, K Schärer, V Lenhard, A M Wingen, G Opelz

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Abstract

Ninety-four children with idiopathic nephrotic syndrome (17 steroid-resistant with a histological diagnosis of a focal segmental glomerulosclerosis) were typed for HLA-A, B and DR antigens. The patients showed a significant increase of DR7 (58% vs 18%, p less than 0.0001) and of B8-DR3 (27% vs 5%, p less than 0.05). Combination of both markers (DR7 and B8-DR3) was observed in 14 per cent of patients but in none of the controls (relative risk 15.2). Patients with B8-DR3 and DR7 had a more severe course of INS.

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HLA表型与儿童特发性肾病综合征。

94例特发性肾病综合征患儿(17例类固醇耐药，组织学诊断为局灶节段性肾小球硬化)进行HLA-A、B和DR抗原分型。患者DR7 (58% vs 18%， p < 0.0001)和B8-DR3 (27% vs 5%， p < 0.05)显著升高。在14%的患者中观察到两种标记物(DR7和B8-DR3)的组合，但在对照组中没有(相对风险为15.2)。B8-DR3和DR7患者的INS病程更为严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association

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