Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

IF 48.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Pub Date : 1984-12-20 DOI:10.1038/312724a0

Diane Pennica, Glenn E. Nedwin, Joel S. Hayflick, Peter H. Seeburg, Rik Derynck, Michael A. Palladino, William J. Kohr, Bharat B. Aggarwal, David V. Goeddel

引用次数: 1658

Abstract

Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.

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人类肿瘤坏死因子：前体结构、表达和与淋巴毒素的同源性

人类肿瘤坏死因子与淋巴毒素的氨基酸序列有大约 30% 的同源性，后者是一种淋巴因子，具有类似的生物特性。重组肿瘤坏死因子可通过在大肠杆菌中表达其互补 DNA 而获得，并可诱导由甲基胆蒽诱导的肉瘤在合成小鼠体内出血性坏死。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature 综合性期刊-综合性期刊

CiteScore

90.00

自引率

1.20%

发文量

3652

审稿时长

3 months

期刊介绍： Nature is a prestigious international journal that publishes peer-reviewed research in various scientific and technological fields. The selection of articles is based on criteria such as originality, importance, interdisciplinary relevance, timeliness, accessibility, elegance, and surprising conclusions. In addition to showcasing significant scientific advances, Nature delivers rapid, authoritative, insightful news, and interpretation of current and upcoming trends impacting science, scientists, and the broader public. The journal serves a dual purpose: firstly, to promptly share noteworthy scientific advances and foster discussions among scientists, and secondly, to ensure the swift dissemination of scientific results globally, emphasizing their significance for knowledge, culture, and daily life.