Acute vascular rejection treated by plasma exchange.

W Fassbinder, W Ernst, H J Stutte, E Scheuermann, U Frei, W Schoeppe
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引用次数: 0

Abstract

Since 1980 we have treated in 14 patients 19 steroid resistant acute vascular rejection (AVR) episodes by plasma filtration (PF). Each episode was treated by six PF with 5L plasma being filtered and simultaneously replaced by 3.5 per cent Albumin-Ringer-lactate. After each PF 20g immunoglobulin (Intraglobin) was given intravenously. In all cases renal function improved following PF. In the long term one graft was lost due to chronic irreversible vascular rejection, all others are still functioning, nine of them six months and eight of them 12 months post PF treatment. They show no signs of rejection. PF with repletion of immunoglobulins after treatment is a simple and safe procedure, which in our hands proved to be quite effective in reversal of AVR.

血浆置换治疗急性血管排斥反应。
自1980年以来,我们通过血浆滤过(PF)治疗了14例19例类固醇抵抗性急性血管排斥(AVR)发作。每次发作用6个PF治疗,5L血浆被过滤,同时用3.5%白蛋白-乳酸林格替代。每次PF后静脉注射免疫球蛋白20g。所有病例的肾功能均在PF治疗后得到改善。长期来看,一例移植物因慢性不可逆的血管排斥而丢失,其余所有移植物仍能正常工作,其中9例在PF治疗后6个月,8例在治疗后12个月。他们没有表现出拒绝的迹象。治疗后的PF与免疫球蛋白的补充是一个简单和安全的程序,在我们的手证明是相当有效的逆转AVR。
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