Steric mapping of some prostaglandin receptor sites.

Z Simon, F Kerek
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Abstract

The Minimal Steric (Topologic) Difference method was applied to map some prostaglandin receptors. Experimental data concerning luteinizing activity of corpora lutea, and pressor respectively depressor activity on sheep blood were considered. The linear correlation coefficients obtained were r = 0.927 (N = 12) for luteinizing activity, r = 0.943 (N = 15) for depressor activity, and r = 0.943 (N = 12) for pressor activity. Similarities and differences between these three receptors are discussed.

一些前列腺素受体位置的立体定位。
应用最小空间(拓扑)差分法对部分前列腺素受体进行了定位。考虑了黄体黄体生成素活性和降压剂对绵羊血液的降压剂活性的实验数据。得到的线性相关系数分别为:促黄体生成素活性r = 0.927 (N = 12),降压剂活性r = 0.943 (N = 15),升压剂活性r = 0.943 (N = 12)。讨论了这三种受体之间的异同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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