Effect of low environmental temperature on adenylate cyclase and phosphodiesterase in rat tissues.

Abstract

Adult rats were exposed to 5 degrees C for 5 and 24 h and thereafter the adenylate cyclase and phosphodiesterase (EC were studied in heart and liver. The cold exposure caused a significant increase in the myocardial adenylate cyclase with a simultaneous decrease of the phosphodiesterase activity. Long term cold exposure exhibited a decrease in the adenylate cyclase activity and an increase in the phosphodiesterase activity in rat liver.