The effect of hemodialysis on levels of cyclic nucleotide-associated hormones in patients with chronic renal failure.

C M Maillet, A J Garber
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引用次数: 4

Abstract

In order to determine the molecular basis for the loss of catecholamine responsiveness in skeletal muscle in chronic azotemia, plasma and serum levels of catecholamines and other hormones whose mechanisms of action are associated in part with cyclic nucleotide mediation were assessed in 37 patients with chronic azotemia. Samples were obtained prior to and immediately following conventional hemodialysis. Plasma epinephrine and norepinephrine levels in patients predialysis were increased 50% and 25% respectively compared to control subjects. Levels of insulin, prolactin, aldosterone and renin were also in creased in azotemic patients prior to dialysis. Conventional hemodialysis reduced serum levels of growth hormone, but had no effect of the elevated levels of all other hormones found in patients predialysis. In particular, plasma epinephrine and norepinephrine levels were unaffected by hemodialysis. Despite these findings, hemodialysis did reduce to normal levels the elevated plasma levels of cyclic AMP and cyclic GMP observed in uremic subjects predialysis. These data are consistent with increased adrenergic outflow in patients with chronic azotemia, and suggest a mechanism of homologous desensitization of the catecholamine receptor adenylyl cyclase unit in chronic azotemia.

血液透析对慢性肾功能衰竭患者环核苷酸相关激素水平的影响。
为了确定慢性氮血症骨骼肌儿茶酚胺反应性丧失的分子基础,对37例慢性氮血症患者的血浆和血清儿茶酚胺和其他作用机制部分与环核苷酸介导相关的激素水平进行了评估。在常规血液透析之前和之后立即获得样本。与对照组相比,透析前患者血浆肾上腺素和去甲肾上腺素水平分别升高50%和25%。氮素血症患者在透析前胰岛素、催乳素、醛固酮和肾素水平也有所升高。常规血液透析降低了生长激素的血清水平,但对透析前患者发现的所有其他激素水平升高没有影响。特别是,血浆肾上腺素和去甲肾上腺素水平不受血液透析影响。尽管有这些发现,血液透析确实将尿毒症患者透析前血浆中升高的环AMP和环GMP水平降至正常水平。这些数据与慢性氮质血症患者肾上腺素能外流增加一致,并提示慢性氮质血症患者儿茶酚胺受体腺苷酸环化酶单元的同源脱敏机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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