Poly(5-methoxycytidylic acid)

Abstract

Poly(5-methoxycytidylic acid) [poly(mo⁵C)] has been prepared by polymerization of 5-methoxycytidine diphosphate with polynucleotide phosphorylase. The poly(mo⁵C) was of high molecular weight and formed a 1 : 1 hybrid with poly(I). Although the $\text{T}{}_{\mathrm{<mtext>m</mtext>}}$ of this hybrid is higher than that of poly(I) · poly(C) in 0.1 M salt, poly(I) · poly(mo⁵C) is not an inducer of interferon.