Glutamine-induced alterations in the content of brain amino acid neurotransmitters in rats with different alcohol motivation.

Substance and alcohol actions/misuse Pub Date : 1984-01-01
Ostrovsky SYu
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Abstract

The 10-day administration of glutamine (500 mg/kg per day) with the drinking water to adult albino rats with different alcohol motivation resulted in a significant increase in the content of glutamate, GABA and taurine in the brain. The level of glycine was decreased only in the ethanol-preferring animals. The results obtained are discussed in terms of a possible role of the amino acid neurotransmitters, particularly GABA, in the antialcoholic action of glutamine.

谷氨酰胺诱导不同酒精动机大鼠脑氨基酸神经递质含量的变化。
不同饮酒动机的成年白化病大鼠在饮水中给予谷氨酰胺(500 mg/kg /天)10天后,脑内谷氨酸、GABA和牛磺酸含量显著增加。甘氨酸水平只在偏爱乙醇的动物中下降。所得的结果讨论了氨基酸神经递质,特别是GABA,在谷氨酰胺的抗酒精作用方面的可能作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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