Pharmacologic investigation of compounds related to 3,4-methylenedioxyamphetamine (MDA).

Substance and alcohol actions/misuse Pub Date : 1984-01-01
W M Davis, R F Borne
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Abstract

The 3-aminobutane homolog (HMDA) of 3,4-methylenedioxyamphetamine (MDA) was synthesized and compared to MDA for acute pharmacologic/toxicologic properties in mice. The lethality of intraperitoneal doses of HMDA equalled or exceeded that of MDA, depending on whether mice were grouped or isolated after dosing. All deaths with HMDA occurred by 6 hours, while many were delayed to 6-24 hours for MDA, particularly in the aggregated condition. Rather similar response patterns were seen for the N-methylated derivatives of MDA and HMDA. Catecholaminergic receptor blockers, haloperidol, propranolol and phenoxybenzamine, which previously were found protective against MDA lethality, were ineffective against HMDA. However, phenoxybenzamine supplemented a protective action of phenobarbital toward HMDA lethality. The dose-related pattern of locomotor activity effects of HMDA differed from the one seen for MDA, which has been suggested to characterize hallucinogenic agents. Thus, HMDA differs qualitatively in actions from MDA and tends to be more toxic acutely for mice.

3,4-亚甲基二氧安非他明(MDA)相关化合物的药理学研究。
合成了3,4-亚甲基二氧安非他明(MDA)的3-氨基丁烷同源物(HMDA),并与MDA比较了小鼠的急性药理学/毒理学特性。HMDA腹腔注射剂量的致死率等于或超过MDA,这取决于小鼠在给药后是分组还是分离。所有HMDA的死亡都发生在6小时前,而许多MDA的死亡延迟到6-24小时,特别是在聚集性疾病中。在MDA和HMDA的n -甲基化衍生物中观察到相当相似的反应模式。儿茶酚胺能受体阻滞剂、氟哌啶醇、普萘洛尔和苯氧苄胺,这些先前被发现对MDA有保护作用的药物,对HMDA无效。然而,苯氧苄胺补充了苯巴比妥对HMDA致死率的保护作用。HMDA对运动活动影响的剂量相关模式与MDA不同,这被认为是致幻剂的特征。因此,HMDA在作用上与MDA有质的不同,对小鼠的急性毒性更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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