The ethanol withdrawal syndrome in the rat: effects of drug treatment on adrenal gland and urinary catecholamines.

Substance and alcohol actions/misuse Pub Date : 1982-01-01
M A Adams, M Hirst
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Abstract

It has been found that a short period of severe intoxication with ethanol produces a marked reduction of adrenal catecholamines. Animals so treated demonstrate moderate to severe withdrawal signs. Accordingly, adrenal and urinary catecholamines were determined in rats undergoing withdrawal after treatment with several drugs known to modify sympathetic function. The depressant diazepam obtained withdrawal severity without altering peripheral catecholamines, propranolol reduced urinary catecholamines and transiently ameliorated withdrawal, whereas hexamethonium elevated urinary catecholamines and enhanced the severity of withdrawal. No drug treatment modified adrenal catecholamine levels. In this model the attenuation of adrenergic function has no consistent influence on the manifestation of withdrawal after ethanol.

大鼠乙醇戒断综合征:药物治疗对肾上腺和尿儿茶酚胺的影响。
研究发现,短时间的酒精严重中毒会导致肾上腺儿茶酚胺的显著减少。接受这种治疗的动物表现出中度至重度戒断症状。因此,在用几种已知的改变交感神经功能的药物治疗后停药的大鼠中,测定肾上腺素和尿儿茶酚胺。抑制剂地西泮在不改变外周儿茶酚胺的情况下加重戒断程度,心得安降低尿儿茶酚胺并短暂改善戒断,而六甲索铵升高尿儿茶酚胺并加重戒断程度。没有药物治疗改变肾上腺儿茶酚胺水平。在该模型中,肾上腺素能功能的衰减对乙醇后戒断的表现没有一致的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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