{"title":"[Platinum complexes as radiosensitizers in radiotherapy].","authors":"M C López Zúmel, M V Alvarez, L Santos Peinado","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The authors study the radiosensitizing effect of cisplatinum, cis-dichloroethylenediamine platinum (II), and cis-dichlorobis-cyclohexylamine platinum (II) by the of TC-SV40 cells radiated under aerobic and hypoxic conditions. Cis-platinum shows the highest radiosensitizing activity but is very toxic. Perhaps cis-dischloro-bis-cyclohexylamine platinum (II) could be assayed as a less toxic radiosensitizing agent. On the other hand, DNA synthesis is studied in mouse spleen and TC-SV40 cells labeled with tritiated thymidine. Cis-platinum inhibitory activity is related to the preincubation time, cis-dichloroethylenediamine platinum(II) does not inhibit the semiconservative synthesis and stimulates the repair synthesis of DNA, and cis-dichloro-bis-cyclohexylamine platinum (II) produces a 60 per 100 inhibition of the semiconservative synthesis and a smaller inhibition of the repair synthesis.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"227-36"},"PeriodicalIF":0.0000,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de oncologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The authors study the radiosensitizing effect of cisplatinum, cis-dichloroethylenediamine platinum (II), and cis-dichlorobis-cyclohexylamine platinum (II) by the of TC-SV40 cells radiated under aerobic and hypoxic conditions. Cis-platinum shows the highest radiosensitizing activity but is very toxic. Perhaps cis-dischloro-bis-cyclohexylamine platinum (II) could be assayed as a less toxic radiosensitizing agent. On the other hand, DNA synthesis is studied in mouse spleen and TC-SV40 cells labeled with tritiated thymidine. Cis-platinum inhibitory activity is related to the preincubation time, cis-dichloroethylenediamine platinum(II) does not inhibit the semiconservative synthesis and stimulates the repair synthesis of DNA, and cis-dichloro-bis-cyclohexylamine platinum (II) produces a 60 per 100 inhibition of the semiconservative synthesis and a smaller inhibition of the repair synthesis.