[Platinum complexes as radiosensitizers in radiotherapy].

Revista espanola de oncologia Pub Date : 1984-01-01
M C López Zúmel, M V Alvarez, L Santos Peinado
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引用次数: 0

Abstract

The authors study the radiosensitizing effect of cisplatinum, cis-dichloroethylenediamine platinum (II), and cis-dichlorobis-cyclohexylamine platinum (II) by the of TC-SV40 cells radiated under aerobic and hypoxic conditions. Cis-platinum shows the highest radiosensitizing activity but is very toxic. Perhaps cis-dischloro-bis-cyclohexylamine platinum (II) could be assayed as a less toxic radiosensitizing agent. On the other hand, DNA synthesis is studied in mouse spleen and TC-SV40 cells labeled with tritiated thymidine. Cis-platinum inhibitory activity is related to the preincubation time, cis-dichloroethylenediamine platinum(II) does not inhibit the semiconservative synthesis and stimulates the repair synthesis of DNA, and cis-dichloro-bis-cyclohexylamine platinum (II) produces a 60 per 100 inhibition of the semiconservative synthesis and a smaller inhibition of the repair synthesis.

[铂配合物在放射治疗中的放射增敏剂]。
作者通过TC-SV40细胞在有氧和缺氧条件下辐射,研究顺铂、顺二氯乙二胺铂(II)和顺二氯环己胺铂(II)的放射增敏效应。顺铂显示出最高的放射致敏活性,但毒性很大。或许顺式二氯双环己胺铂(II)可以作为毒性较小的放射增敏剂进行试验。另一方面,用氚化胸腺嘧啶标记小鼠脾脏和TC-SV40细胞研究DNA合成。顺式铂的抑制活性与预孵育时间有关,顺式二氯乙二胺铂(II)不抑制半保留合成而刺激DNA的修复合成,顺式二氯双环己胺铂(II)对半保留合成产生60 / 100的抑制作用,对修复合成产生较小的抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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