{"title":"Experimental study of a new psychosedative drug: HS-2314","authors":"G. Sierra, C. Acuna, J. Otero, G. Docampo","doi":"10.1016/0028-3908(69)90008-2","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of HS-2314, a new psychosedative drug, was determined in unanesthetized, unrestrained cats and rabbits. The effect was measured by the use of several electro-physiological techniques and behavioural observations. A comparative study with chlordiazepoxide, diazepam and chlorpromazine was performed.</p><p>It was found that HS-2314 reduced aggressiveness in cats, abolished the amygdala spindles induced by presentation of a rat and evoked synchronization of the EEG in several cortical and subcortical structures. HS-2314 seems to be clearly differentiated from diazepam, chlordiazepoxide and chlorpromazine.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 2","pages":"Pages 153-160, IN8"},"PeriodicalIF":0.0000,"publicationDate":"1969-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90008-2","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
The effect of HS-2314, a new psychosedative drug, was determined in unanesthetized, unrestrained cats and rabbits. The effect was measured by the use of several electro-physiological techniques and behavioural observations. A comparative study with chlordiazepoxide, diazepam and chlorpromazine was performed.
It was found that HS-2314 reduced aggressiveness in cats, abolished the amygdala spindles induced by presentation of a rat and evoked synchronization of the EEG in several cortical and subcortical structures. HS-2314 seems to be clearly differentiated from diazepam, chlordiazepoxide and chlorpromazine.
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