Whole and polysaccharide powdered Sporisorium reilianum improves DSS-induced colitis in BALB/c mice by modulating gut microbiota

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2021-04-01 DOI:10.1016/j.jff.2021.104409

Ximing Yang , Shengnan Li , Chao Wang , Yuhang Lou , Xinxiu Xia , Hongyan Xu

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引用次数: 11

Abstract

This study aimed to evaluate whether the whole powder (SRPW) and polysaccharide (SRPS) from Sporisorium reilianum could modulate the gut microbiota in mice with dextran sulfate sodium (DSS) induced colitis. The results showed that the disease and structure of colon tissue were improved, and the balance of colonic mucosal related factors was restored. Compared to ulcerative colitis (UC) mice, the composition and diversity of gut microbiota were significantly increased. Specifically, the abundance of Bacteroidetes, TM7, and Proteobacteria at the phylum level and Bacteroides, Coprobacillus, Streptococcus, and Lactobacillus at the genus level were restored to normal levels. Furthermore, functional analysis revealed that carbohydrate, amino acid, and energy metabolism were regulated by S. reilianum, thus promoting the recovery of the intestinal mucosal structure. These findings indicated the possibility of S. reilianum as a functional food to prevent colitis through the gut microbiota.

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全粉和多糖粉末状芽孢菌通过调节肠道菌群改善dss诱导的BALB/c小鼠结肠炎

本研究旨在探讨酵母全粉(SRPW)和多糖(SRPS)对葡聚糖硫酸钠(DSS)诱导结肠炎小鼠肠道菌群的调节作用。结果显示，大鼠结肠组织病变及结构得到改善，结肠黏膜相关因子恢复平衡。与溃疡性结肠炎(UC)小鼠相比，肠道菌群的组成和多样性显著增加。其中门水平的拟杆菌门(Bacteroidetes)、TM7、变形杆菌门(Proteobacteria)和属水平的拟杆菌门(Bacteroides)、副杆菌门(Coprobacillus)、链球菌门(Streptococcus)、乳酸杆菌门(Lactobacillus)丰度恢复正常。此外，功能分析显示，肠球菌调节碳水化合物、氨基酸和能量代谢，从而促进肠粘膜结构的恢复。这些发现表明，弧菌可能是一种功能性食品，通过肠道微生物群预防结肠炎。

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.

文献相关原料

公司名称	产品信息	采购帮参考价格
上海源叶	Dextran sulfate sodium	￥30.00~￥402851.90
上海源叶	dextran sulfate sodium (DSS)