The effects of strychnine on the inhibition of interneurons by glycine and γ-aminobutyric acid

Abstract

The effects of strychnine on the inhibition of spinal interneurons produced by glycine and GABA was studied by means of iontophoretic application from multibarrel electrodes. The actions of glycine were more effectively blocked by strychnine than were those of GABA. The data suggest that a non-competitive type of antagonism exists between strychnine and these inhibitory amino acids.