{"title":"The effects of triethylcholine and hemicholinium-3 on the acetylcholine content of rat brain","authors":"Paul Slater","doi":"10.1016/0028-3908(68)90041-5","DOIUrl":null,"url":null,"abstract":"<div><p>Intraventricular injections of triethylcholine made in conscious rats produced catatonia preceded in a number of animals by a seizure. Hemicholinium-3 also produced a brief period of catatonia but any seizures which occurred did so only after an interval of about 1 hr. Both compounds reduced the total amount of brain acetylcholine and this effect was prevented when choline was administered at the same time. A small intraventricular dose of triethylcholine, which was not sufficient to affect the total amount of brain acetylcholine, did reduce the amount of free acetylcholine. A larger dose decreased both the free and bound components. An intraperitoneal injection of triethylcholine had no effect on brain acetylcholine. The catatonia and seizures produced by triethylcholine and hemicholinium-3 cannot be related to any apparent changes in either brain acetylcholine content or acetylcholinesterase activity.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"7 5","pages":"Pages 421-427"},"PeriodicalIF":0.0000,"publicationDate":"1968-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(68)90041-5","citationCount":"38","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390868900415","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 38
Abstract
Intraventricular injections of triethylcholine made in conscious rats produced catatonia preceded in a number of animals by a seizure. Hemicholinium-3 also produced a brief period of catatonia but any seizures which occurred did so only after an interval of about 1 hr. Both compounds reduced the total amount of brain acetylcholine and this effect was prevented when choline was administered at the same time. A small intraventricular dose of triethylcholine, which was not sufficient to affect the total amount of brain acetylcholine, did reduce the amount of free acetylcholine. A larger dose decreased both the free and bound components. An intraperitoneal injection of triethylcholine had no effect on brain acetylcholine. The catatonia and seizures produced by triethylcholine and hemicholinium-3 cannot be related to any apparent changes in either brain acetylcholine content or acetylcholinesterase activity.
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