{"title":"Molecularly imprinted polymer (MIP) based electrochemical sensors and their recent advances in health applications","authors":"Lue Wang , Matthew Pagett , Wei Zhang","doi":"10.1016/j.snr.2023.100153","DOIUrl":null,"url":null,"abstract":"<div><p>Molecularly imprinted polymer (MIP)-based electrochemical sensors have received growing attention over past decades owing to its robust nature, simple electrochemical control for template removal and cavity regeneration, and go-as-you-please cavity designs into various geometries specific to target analytes. The strength of MIP scheme, in combination with the advantages of electrochemical sensing techniques such as operation simplicity, rapid response, and high sensitivity, provide a synergistic effort to form a highly effective sensing platform suitable for an extremely wide range of interest. In this Review, the introduction of MIP and the comparison between electrochemical sensing methods and other detection strategies are briefly discussed. Then, a broad range of analytes determined using MIP-based electrochemical sensors are listed and critically reviewed, mainly focusing on the applied electrochemical technique, presented linear range along with limit of detection (LOD), biological fluid used in real testing, and pretreatment for real sample. Other sensor performances like selectivity towards analyte, signal repeatability, sensor-to-sensor reproducibility, and stability, are carefully compared with other reported papers. MIP sensors fabricated via the nanoMIP technology, and the ones integrated with portable analyzers, are given in more details as good results are always observed in such instances. Finally, a conclusion regarding recent advances on MIP-based electrochemical sensors is presented, followed by current issues and future development depicted at the last section of the Review.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":null,"pages":null},"PeriodicalIF":6.5000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensors and Actuators Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666053923000164","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 14
Abstract
Molecularly imprinted polymer (MIP)-based electrochemical sensors have received growing attention over past decades owing to its robust nature, simple electrochemical control for template removal and cavity regeneration, and go-as-you-please cavity designs into various geometries specific to target analytes. The strength of MIP scheme, in combination with the advantages of electrochemical sensing techniques such as operation simplicity, rapid response, and high sensitivity, provide a synergistic effort to form a highly effective sensing platform suitable for an extremely wide range of interest. In this Review, the introduction of MIP and the comparison between electrochemical sensing methods and other detection strategies are briefly discussed. Then, a broad range of analytes determined using MIP-based electrochemical sensors are listed and critically reviewed, mainly focusing on the applied electrochemical technique, presented linear range along with limit of detection (LOD), biological fluid used in real testing, and pretreatment for real sample. Other sensor performances like selectivity towards analyte, signal repeatability, sensor-to-sensor reproducibility, and stability, are carefully compared with other reported papers. MIP sensors fabricated via the nanoMIP technology, and the ones integrated with portable analyzers, are given in more details as good results are always observed in such instances. Finally, a conclusion regarding recent advances on MIP-based electrochemical sensors is presented, followed by current issues and future development depicted at the last section of the Review.
期刊介绍:
Sensors and Actuators Reports is a peer-reviewed open access journal launched out from the Sensors and Actuators journal family. Sensors and Actuators Reports is dedicated to publishing new and original works in the field of all type of sensors and actuators, including bio-, chemical-, physical-, and nano- sensors and actuators, which demonstrates significant progress beyond the current state of the art. The journal regularly publishes original research papers, reviews, and short communications.
For research papers and short communications, the journal aims to publish the new and original work supported by experimental results and as such purely theoretical works are not accepted.