Development of a porous layer-by-layer microsphere with branched aliphatic hydrocarbon porogens

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-02-01 DOI:10.1016/j.nano.2022.102644

Farah Shahjin PhD , Milankumar Patel MS , Mahmudul Hasan MPharm , Jacob D. Cohen BS , Farhana Islam BPharm , Md Ashaduzzaman BSc , Mohammad Ullah Nayan BPharm , Mahadevan Subramaniam PhD , You Zhou PhD , Irene Andreu PhD , Howard E. Gendelman MD , Bhavesh D. Kevadiya PhD

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Abstract

Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning, biodegradation, and cargo encapsulation. How uniformity of pore size affects therapeutic delivery remains an area of active investigation. Herein, we characterize six branched aliphatic hydrocarbon-based porogen(s) produced to create pores in single and multilayered microspheres. The porogens are composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid), and polylactic acid polymers within porous multilayered microspheres. These serve as controlled effective drug and vaccine delivery platforms.

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具有支链脂肪烃成孔剂的多孔层状微球的研制

多孔聚合物微球应用于生物治疗、组织工程和再生医学。孔隙率决定了货物的运输和释放，这与聚合物的物理化学性质一致。这些包括材料调整、生物降解和货物封装。孔径均匀性如何影响治疗递送仍然是一个积极研究的领域。在此，我们描述了六种支链脂肪族烃基孔隙剂，这些孔隙剂可以在单层和多层微球中形成孔隙。多孔性微球由生物相容性聚己内酯、聚乳酸-羟基乙酸和聚乳酸聚合物组成。这些平台是受控制的有效药物和疫苗输送平台。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.