Biosynthesis of trichothecene mycotoxins in Fusarium culmorum cultures.

Zeitschrift fur Naturforschung. Section C, Biosciences Pub Date : 1985-07-01 DOI:10.1515/znc-1985-7-810

N C Baldwin, B W Bycroft, P M Dewick, J Gilbert, I Holden

引用次数: 8

Abstract

A high yielding production of the trichothecene mycotoxin 3-acetyldeoxynivalenol (3-AcDON) in cultures of Fusarium culmorum is described. By supplying [14C]acetate, 14C-labelled 3-AcDON suitable for further metabolic studies has been obtained. The pattern of labelling has been ascertained by using 13C-labelled acetate precursors, and is in line with established biosynthetic data. A second trichothecene produced in significant amounts by F. culmorum has been identified as 3 alpha, 15-diacetoxy-7 alpha, 8 alpha-dihydroxy-12, 13-epoxytrichothec-9-ene (7 alpha, 8 alpha-dihydroxycalonectrin).

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镰刀菌培养中毛霉毒素的生物合成。

在culmorum镰刀菌的培养中高产地生产毛霉毒素3-乙酰脱氧雪腐镰刀菌醇(3-AcDON)。通过供应[14C]醋酸盐，获得了适合进一步代谢研究的14C标记的3-AcDON。通过使用13c标记的醋酸前体确定了标记模式，并且与已建立的生物合成数据一致。第二种毛霉烯经鉴定为3 α， 15-二乙酰氧基-7 α， 8 α -二羟基- 12,13 -环氧毛霉-9-烯(7 α， 8 α -二羟基calonectrin)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zeitschrift fur Naturforschung. Section C, Biosciences

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