{"title":"Correlations of sinus, conical elevation, median depression of the lower lip and types of oral clefts","authors":"R. Ranta","doi":"10.1016/S0300-9785(85)80053-3","DOIUrl":null,"url":null,"abstract":"<div><p>The incidence of autosomal dominantly inherited Van der Woude's syndrome among Finnish patients with cleft lip and palate CL(P) and with isolated cleft palate (CP) is approximately 2.5%. The incidence of conical elevation of the lower lip (CE) is 39% in CP and 0.8% in CL(P) patients. A pathogenetic similarity of sinuses and CE's was noted. The following classification was used to study associations between sinuses and CE's: (1) sinus; bilateral, unilateral, atypical; (2) CE: bilateral, unilateral; (3) median depression of the lower lip (MD); (4) combined sinus and CE; (5) combined CE and MD. According to the classification developed, a group of 77 sinus patients and 156 CE and/or MD patients was classified in subgroups of CL(P), CP, Pierre Robin anomalad (PR) and non-cleft subjects. The findings were: the sinus was bilateral on 52%, unilateral in 34% and atypical in 14%; the CE without associated sinus was bilateral in all cases; the sinus was associated with CE in 77% of all sinus subjects. The highly increased incidence of the CE in the CP (92%) and in the CL(P) (61%) sinus groups compared to the incidences of CE in these groups in general (39% and 0.8%) shows a close relationship between these 2 disorders of the lower lip, but the similarity of the genetic etiology still remains unclear.</p></div>","PeriodicalId":14224,"journal":{"name":"International journal of oral surgery","volume":"14 6","pages":"Pages 479-484"},"PeriodicalIF":0.0000,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-9785(85)80053-3","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of oral surgery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300978585800533","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
The incidence of autosomal dominantly inherited Van der Woude's syndrome among Finnish patients with cleft lip and palate CL(P) and with isolated cleft palate (CP) is approximately 2.5%. The incidence of conical elevation of the lower lip (CE) is 39% in CP and 0.8% in CL(P) patients. A pathogenetic similarity of sinuses and CE's was noted. The following classification was used to study associations between sinuses and CE's: (1) sinus; bilateral, unilateral, atypical; (2) CE: bilateral, unilateral; (3) median depression of the lower lip (MD); (4) combined sinus and CE; (5) combined CE and MD. According to the classification developed, a group of 77 sinus patients and 156 CE and/or MD patients was classified in subgroups of CL(P), CP, Pierre Robin anomalad (PR) and non-cleft subjects. The findings were: the sinus was bilateral on 52%, unilateral in 34% and atypical in 14%; the CE without associated sinus was bilateral in all cases; the sinus was associated with CE in 77% of all sinus subjects. The highly increased incidence of the CE in the CP (92%) and in the CL(P) (61%) sinus groups compared to the incidences of CE in these groups in general (39% and 0.8%) shows a close relationship between these 2 disorders of the lower lip, but the similarity of the genetic etiology still remains unclear.
芬兰唇腭裂CL(P)和孤立性腭裂(CP)患者常染色体显性遗传Van der Woude综合征的发生率约为2.5%。在CP患者中,下唇锥形凸起(CE)的发生率为39%,在CL(P)患者中为0.8%。注意到鼻窦和CE的发病机制相似。使用以下分类来研究鼻窦与CE之间的关系:(1)鼻窦;双侧,单侧,非典型;(2) CE:双边、单边;(3)下唇正中凹陷(MD);(4)鼻窦与CE联合;(5)合并CE和MD。将77例鼻窦患者和156例CE和/或MD患者分为CL(P)、CP、Pierre Robin anomalad (PR)和非裂患者亚组。结果:鼻窦双侧52%,单侧34%,非典型14%;无伴鼻窦的CE均为双侧;在所有鼻窦患者中,77%的鼻窦与CE有关。与普通组的CE发生率(39%和0.8%)相比,CP(92%)和CL(P)(61%)鼻窦组CE的发生率高,表明这两种下唇疾病之间关系密切,但遗传病因的相似性尚不清楚。