A mild and selective method for N-Boc deprotection

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2002-01-21 Epub Date: 2001-11-30 DOI:10.1016/S0040-4039(01)02225-0

Sylvain Routier, Laurence Saugé, Nathalie Ayerbe, Gérard Coudert, Jean-Yves Mérour

引用次数: 55

Abstract

A new mild method to remove N-tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid- and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes.

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一种温和、选择性的N-Boc脱保护方法

报道了一种利用四氢呋喃回流法脱除n -叔丁基氧羰基的温和新方法。在所有情况下，相应的无氮产物都得到了良好的产率。这些反应对酸和碱敏感的基团，如叔丁基和烷基酯、醛具有选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.