Two-pool model analysis of data in hemodialysis by means of programmable pocket calculator TI 59

Abstract

Four parameters of a two-pool model are evaluated by an iterative method using the explicit solutions of the linear differential equations. For this it was presumed that the residual renal clearance is sufficiently small. Five data pairs of measured plasma concentrations c_i for the time points t_i (i = 0 to 4), as well as the dialyzer and residual renal clearances (K_D and K_R), must be given and put in the calculator. A sample run is shown for urea kinetics. The parameter estimation takes about 10 min. The program is suitable to assist in the individualization of dialysis therapy.