Inhibition of voluntary ethanol intake in rats by a combination of dihydroergotoxine and thioridazine.

Alcohol and drug research Pub Date : 1987-01-01

F Fadda, F Franch, E Mosca, R Meloni, G L Gessa

引用次数: 0

Abstract

Dihydroergotoxine (DHET) decreased voluntary ethanol intake in rats selected for their stable ethanol preference (mean daily ethanol intake 8 g/kg). DHET inhibition was markedly potentiated by thioridazine. The potentiation is explained with a synergistic inhibitory effect on dopaminergic transmission: that is, DHET acting on dopamine (DA) autoreceptors and thioridazine preferentially inhibiting postsynaptic DA receptors.

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双氢麦角毒素和噻嗪联合使用对大鼠自愿乙醇摄入的抑制作用。

二氢麦角毒素(DHET)减少了选择稳定乙醇偏好的大鼠的自愿乙醇摄入量(平均每日乙醇摄入量为8 g/kg)。硫硝嗪能显著增强对DHET的抑制作用。这种增强可以解释为对多巴胺能传递的协同抑制作用:即DHET作用于多巴胺(DA)自身受体，而硫胺嘧啶优先抑制突触后DA受体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alcohol and drug research

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