Monte Carlo Evaluation of Scalp Dose in Whole Brain Radiotherapy

IF 3.5 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2026-10-27 DOI:10.1016/j.radphyschem.2026.114580

Felipe Beraldo da Cruz, Fernanda Quadros Fuzato, Victor Luiz Ossick Evangelista, Cintia de Almeida Ribeiro, Guenda Meffe, Sara Ramella, Lucio Pereira Neves, Ana Paula Perini

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Abstract

This study investigated the scalp dose during whole-brain radiotherapy (WBRT) using Monte Carlo simulations. The dose-depth relationship in the scalp was established by modelling structures at different depths derived from the ICRP 145 MRCP skin surface using Blender. Different scalp subdivisions were also defined to provide a more detailed analysis of the dose distribution. The results showed that the most superficial scalp region (0-1 mm) received a mean dose of 11.94 Gy, whereas the hair follicle layer (4-5 mm) received a mean dose of 22.31 Gy, demonstrating a substantial increase in dose with depth. Regional analysis at the follicular depth revealed spatial heterogeneity, with mean doses ranging from 17.35 Gy in the vertex to 31.96 Gy in the occipital region, and an overall mean of 24.82 Gy. Because these region-specific mean doses remained below the 36 Gy threshold for permanent alopecia but uniformly exceeded the 20 Gy threshold for transient hair loss, the occurrence of widespread temporary alopecia is expected. These findings highlight the clinical relevance of evaluating depth-resolved and region-specific dose distributions in the scalp during WBRT.

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全脑放疗中头皮剂量的蒙特卡罗评价

本研究利用蒙特卡罗模拟研究了全脑放疗（WBRT）期间的头皮剂量。通过使用Blender对来自ICRP 145 MRCP皮肤表面不同深度的结构进行建模，建立了头皮的剂量-深度关系。为了提供更详细的剂量分布分析，还定义了不同的头皮细分。结果表明，头皮最表层（0-1 mm）的平均剂量为11.94 Gy，而毛囊层（4-5 mm）的平均剂量为22.31 Gy，剂量随深度的增加而显著增加。卵泡深度的区域分析显示出空间异质性，平均剂量范围从顶点的17.35 Gy到枕部的31.96 Gy，总体平均剂量为24.82 Gy。由于这些区域特异性的平均剂量仍然低于永久性脱发的36 Gy阈值，但一致超过短暂性脱发的20 Gy阈值，预计会发生广泛的暂时性脱发。这些发现强调了在WBRT期间评估头皮深度分辨和区域特异性剂量分布的临床相关性。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.