Treatment Outcomes in Osteosarcoma of the Head and Neck: A Systematic Review and Meta-Analysis.

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2026-10-28 DOI:10.1002/hed.70452

Angela Magri, Andrea Quaiattini, Alex Mlynarek, Keith Richardson, Michael Hier, Nader Sadeghi, Ramy Saleh, Ahmed Aoude, Khalil Sultanem, Salvatore Di Maio, Tamara Mijovic, Marco Mascarella, Emily Kay-Rivest

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引用次数: 0

Abstract

Background: Head and neck osteosarcomas (HNOS) are rare, accounting for ~1% of head and neck malignancies. This study systematically evaluated the role of chemotherapy (CT) and radiotherapy (RT) on survival outcomes.

Methods: A systematic review and meta-analysis were performed following PRISMA guidelines across six databases. Treatment arms included surgery alone or combined with CT and/or RT, given in neoadjuvant or adjuvant settings. Primary outcomes were overall survival (OS) and disease-free survival (DFS).

Results: Thirty-one studies comprising 2006 patients were included. Jaw tumors had superior OS compared to skull base tumors. CT significantly improved OS (HR 0.75, 95% CI 0.62-0.89) and DFS (HR 0.79, 95% CI 0.63-0.98), particularly in the neoadjuvant setting, whereas RT showed no survival benefit.

Conclusions: Systemic therapy in combination with surgery improves OS and DFS in HNOS, reinforcing its importance as part of curative-intent treatment.

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头颈部骨肉瘤的治疗结果：系统回顾和荟萃分析。

背景：头颈部骨肉瘤（HNOS）罕见，约占头颈部恶性肿瘤的1%。本研究系统地评估了化疗（CT）和放疗（RT）对生存结果的作用。方法：根据PRISMA指南对6个数据库进行系统回顾和荟萃分析。治疗组包括单独手术或联合CT和/或RT，在新辅助或辅助环境下给予。主要结局是总生存期（OS）和无病生存期（DFS）。结果：纳入了31项研究，包括2006例患者。颌骨肿瘤的OS优于颅底肿瘤。CT显着改善了OS （HR 0.75, 95% CI 0.62-0.89）和DFS (HR 0.79, 95% CI 0.63-0.98)，特别是在新辅助设置中，而RT没有显示生存益处。结论：全身治疗联合手术改善了HNOS的OS和DFS，加强了其作为治疗意图治疗的一部分的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.