Design principles and functionalization strategies of injectable hydrogels based on natural polymers for advanced wound healing.

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2026-10-27 DOI:10.1016/j.bioadv.2026.215268

Ankita Singh, Aharnish Maurya, Shubham Yadav, Arjun Kumar, Shailendra Singh Shera

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引用次数: 0

Abstract

Preformed hydrogel also known as conventional hydrogel has been widely used for wound healing purposes over the past decades. One of the major disadvantages of preformed hydrogel is that they can be applied at the exterior wound surface and fails to distribute in case of irregularly shaped wounds. These disadvantages have led to development of injectable hydrogel system with focus on using natural polymers such as proteins and polysaccharides. The current research flavor is not only injectability but injectability with multifunctionality especially anti-microbial properties. However, developing an injectable hydrogel for wound healing withmultifunctions is complex because of consideration of several design factors such as molecular weight, rheological behavior, gelation characteristics, biocompatibility, surface characteristics, antimicrobial activity and complexity of wound healing process. The objective of this review is to highlight different aspect of design criterion suitably used for developing injectable hydrogel from natural polymers, functionalization strategy and a review of usage of these criterions in current literature.

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基于天然聚合物的高级伤口愈合注射水凝胶的设计原理和功能化策略。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!