Neural mechanisms of cognitive dysfunction in depression: dual-task event-related potentials and task-phase-dependent EEG functional connectivity.

IF 4.6 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2026-07-29 DOI:10.1186/s12888-026-08436-9

Yongxiang Zhang, Jing Li, Huifei Zhang, Guangda Liu, Xin Yang, Yudan Lv

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引用次数: 0

Abstract

Objective: To investigate the neurophysiological features underlying depression-related cognitive dysfunction via dual-task event-related potential (ERP) and task-phase-dependent electroencephalography (EEG) functional connectivity analysis.

Methods: Thirty patients with depression (DP group) and 30 matched healthy controls (HC group) underwent EEG recordings across pre-task resting state, face perception task (indexed by N170), face mismatch conflict monitoring task (indexed by N270), and post-task resting state. Functional connectivity was quantified using imaginary coherence (iCoh), with between-group comparisons corrected by Benjamini-Hochberg false discovery rate (FDR). Correlation analyses between electrophysiological metrics and clinical variables were performed in the DP group.

Results: The DP group exhibited prolonged latency and decreased amplitude of N170, prolonged latency and increased amplitude of N270, as well as task-phase-dependent multi-frequency brain network imbalances. In the DP group, longer N170 and N270 latencies were associated with more severe depressive symptoms, whereas task-phase-dependent functional connectivity abnormalities showed no significant associations with clinical variables.

Conclusion: Depression was associated with electrophysiological abnormalities in emotional processing and conflict monitoring, as well as task-phase-dependent brain network imbalances, providing exploratory neurophysiological evidence related to depression-associated cognitive dysfunction.

Clinical trial number: Not applicable.

查看原文本刊更多论文

抑郁症认知功能障碍的神经机制：双任务事件相关电位和任务相依赖的脑电功能连接。

目的：通过双任务事件相关电位（ERP）和任务相依赖脑电图（EEG）功能连通性分析，探讨抑郁症相关认知功能障碍的神经生理特征。方法：30例抑郁症患者（DP组）和30例匹配的健康对照（HC组）分别记录任务前静息状态、面孔感知任务（N170索引）、面孔错配冲突监测任务（N270索引）和任务后静息状态的脑电图。功能连通性用虚相干性（iCoh）量化，组间比较用Benjamini-Hochberg错误发现率（FDR）校正。DP组电生理指标与临床变量的相关性分析。结果：DP组表现为N170潜伏期延长、幅度降低，N270潜伏期延长、幅度增加，任务相依赖性多频脑网络失衡。在DP组中，更长的N170和N270潜伏期与更严重的抑郁症状相关，而任务阶段依赖的功能连接异常与临床变量没有显着关联。结论：抑郁症与情绪处理和冲突监测的电生理异常以及任务相依赖的脑网络失衡有关，为抑郁症相关认知功能障碍提供了探索性的神经生理学证据。临床试验号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.