Gilbert Rodríguez, Abel José Rodríguez-Yparraguirre, Carlos Diego Rodríguez-Yparraguirre, Elza Aguirre, William E López-Rodríguez, Janet E Muñoz-Agreda, Soledad Quezada Berru, Cesar Moreno-Rojo, Guisela P Carbajal-Romero, María de Fátima Arevalo-Oliva, Judy Muñoz-Saenz, Alyssa Hidalgo
{"title":"Advanced Separation Technologies for Cascade Biorefinery Valorization of <i>Capsicum</i> Seed Residues.","authors":"Gilbert Rodríguez, Abel José Rodríguez-Yparraguirre, Carlos Diego Rodríguez-Yparraguirre, Elza Aguirre, William E López-Rodríguez, Janet E Muñoz-Agreda, Soledad Quezada Berru, Cesar Moreno-Rojo, Guisela P Carbajal-Romero, María de Fátima Arevalo-Oliva, Judy Muñoz-Saenz, Alyssa Hidalgo","doi":"10.3390/foods15203699","DOIUrl":null,"url":null,"abstract":"<p><p><i>Capsicum</i> seed waste is an underutilized agro-industrial biomass with considerable potential for the recovery of oils, proteins, phenolic compounds, capsaicinoids, peptides, and other value-added fractions. This study evaluates advanced separation technologies for valorization in a cascade biorefinery, with an emphasis on extraction yield, selectivity, product functionality, sustainability, and technological scalability. A systematic literature search was conducted in Scopus and Web of Science, and the retrieved records were merged and processed using R (version 4.6.1) in RStudio (version 2026.01.2+418) Study selection and presentation were aligned with the PRISMA protocol, resulting in 82 studies included for thematic analysis. The evidence indicates that ultrasound-assisted, enzymatic, aqueous oleosome, pressure-based, membrane, and chromatographic approaches can improve the recovery and selective separation of valuable seed-derived fractions. The reported experimental results include an oleosome recovery of 66.96% by weight, with a potential recovery approaching 90% by weight, and a 73.5% increase in extraction recovery after enzyme-assisted processing. Protein modification and fractionation have also demonstrated opportunities for the development of functional ingredients, bioactive fractions, and biomaterials. However, limited pilot-scale validation, process integration, standardization, techno-economic feasibility, and life-cycle assessments constrain industrial implementation. Future research must prioritize scalable, closed-loop cascade strategies to minimize energy use, solvent consumption, and environmental footprint while maximizing biomass conversion.</p>","PeriodicalId":12386,"journal":{"name":"Foods","volume":"15 20","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13704395/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Foods","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3390/foods15203699","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Capsicum seed waste is an underutilized agro-industrial biomass with considerable potential for the recovery of oils, proteins, phenolic compounds, capsaicinoids, peptides, and other value-added fractions. This study evaluates advanced separation technologies for valorization in a cascade biorefinery, with an emphasis on extraction yield, selectivity, product functionality, sustainability, and technological scalability. A systematic literature search was conducted in Scopus and Web of Science, and the retrieved records were merged and processed using R (version 4.6.1) in RStudio (version 2026.01.2+418) Study selection and presentation were aligned with the PRISMA protocol, resulting in 82 studies included for thematic analysis. The evidence indicates that ultrasound-assisted, enzymatic, aqueous oleosome, pressure-based, membrane, and chromatographic approaches can improve the recovery and selective separation of valuable seed-derived fractions. The reported experimental results include an oleosome recovery of 66.96% by weight, with a potential recovery approaching 90% by weight, and a 73.5% increase in extraction recovery after enzyme-assisted processing. Protein modification and fractionation have also demonstrated opportunities for the development of functional ingredients, bioactive fractions, and biomaterials. However, limited pilot-scale validation, process integration, standardization, techno-economic feasibility, and life-cycle assessments constrain industrial implementation. Future research must prioritize scalable, closed-loop cascade strategies to minimize energy use, solvent consumption, and environmental footprint while maximizing biomass conversion.
辣椒籽废料是一种未充分利用的农业工业生物质，具有相当大的潜力，可以回收油、蛋白质、酚类化合物、辣椒素、肽和其他增值部分。本研究评估了在级联生物精炼厂中用于增值的先进分离技术，重点是萃取率、选择性、产品功能、可持续性和技术可扩展性。在Scopus和Web of Science中进行系统的文献检索，并在RStudio（版本2026.01.2+418）中使用R（版本4.6.1）对检索到的文献进行合并和处理。研究选择和呈现符合PRISMA协议，共纳入82项研究进行专题分析。有证据表明，超声辅助、酶、水相油体、压力基、膜和色谱方法可以提高有价值的种子衍生组分的回收率和选择性分离。实验结果表明：油质体回收率为66.96%（重量比），潜在回收率接近90%（重量比），酶辅助处理后提取回收率提高73.5%。蛋白质修饰和分离也为功能性成分、生物活性组分和生物材料的开发提供了机会。然而，有限的中试规模验证、工艺集成、标准化、技术经济可行性和生命周期评估限制了工业实施。未来的研究必须优先考虑可扩展的闭环级联策略，以最大限度地减少能源使用、溶剂消耗和环境足迹，同时最大限度地提高生物质转化。
期刊介绍：
Foods (ISSN 2304-8158) is an international, peer-reviewed scientific open access journal which provides an advanced forum for studies related to all aspects of food research. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists, researchers, and other food professionals to publish their experimental and theoretical results in as much detail as possible or share their knowledge with as much readers unlimitedly as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, unique features of this journal:
manuscripts regarding research proposals and research ideas will be particularly welcomed
electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material
we also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
