Effects of the Pythagorean Self-Awareness Intervention on total oxidant status and telomere length in breast cancer survivors: A randomized controlled trial.
Maria Charalampopoulou, George C Zografos, Dimitrios Tsakogiannis, Ioanna A Anastasiou, Garyfalia Bletsa, Dimitrios Tryfonopoulos, Panagiotis Daskalakis, George P Chrousos, Flora Bacopoulou, Flora Zagouri, Christina Darviri
{"title":"Effects of the Pythagorean Self-Awareness Intervention on total oxidant status and telomere length in breast cancer survivors: A randomized controlled trial.","authors":"Maria Charalampopoulou, George C Zografos, Dimitrios Tsakogiannis, Ioanna A Anastasiou, Garyfalia Bletsa, Dimitrios Tryfonopoulos, Panagiotis Daskalakis, George P Chrousos, Flora Bacopoulou, Flora Zagouri, Christina Darviri","doi":"10.1016/j.mad.2026.112263","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Psychological stress and health behaviors are associated with oxidative status and telomere biology, but evidence from multidomain interventions in breast cancer survivors remains limited.</p><p><strong>Objective: </strong>To evaluate the effects of the Pythagorean Self-Awareness Intervention (PSAI) on biological, behavioral, and psychosocial outcomes following breast cancer treatment.</p><p><strong>Methods: </strong>In this randomized controlled trial, 120 women were randomized to an eight-week PSAI program or education-only control condition (n = 60 each); 118 were included in the modified intention-to-treat analysis. Primary biological outcomes were serum total oxidant status and PBMC relative telomere T/S ratio. Linear mixed-effects models estimated group × time effects, between-group differences in change, 95% confidence intervals (CIs), and Hedges' g.</p><p><strong>Results: </strong>Total oxidant status decreased more in the intervention group (difference in change, -3.83 μmol/L; 95% CI -7.03 to -0.63; p = 0.020; g = -0.13). Telomere-length change did not differ significantly between groups (-0.170log₂[T/S] units; 95% CI -0.554 to 0.214; p = 0.382; g = -0.23). PSAI also improved physical activity, body weight, sleep, perceived stress, anxiety, and depression.</p><p><strong>Conclusion: </strong>PSAI improved total oxidant status and several patient-relevant outcomes but did not significantly affect telomere-length change. Longer, adequately powered trials with repeated biomarker assessments are require.</p>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":" ","pages":"112263"},"PeriodicalIF":6.5000,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mechanisms of Ageing and Development","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.mad.2026.112263","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Psychological stress and health behaviors are associated with oxidative status and telomere biology, but evidence from multidomain interventions in breast cancer survivors remains limited.
Objective: To evaluate the effects of the Pythagorean Self-Awareness Intervention (PSAI) on biological, behavioral, and psychosocial outcomes following breast cancer treatment.
Methods: In this randomized controlled trial, 120 women were randomized to an eight-week PSAI program or education-only control condition (n = 60 each); 118 were included in the modified intention-to-treat analysis. Primary biological outcomes were serum total oxidant status and PBMC relative telomere T/S ratio. Linear mixed-effects models estimated group × time effects, between-group differences in change, 95% confidence intervals (CIs), and Hedges' g.
Results: Total oxidant status decreased more in the intervention group (difference in change, -3.83 μmol/L; 95% CI -7.03 to -0.63; p = 0.020; g = -0.13). Telomere-length change did not differ significantly between groups (-0.170log₂[T/S] units; 95% CI -0.554 to 0.214; p = 0.382; g = -0.23). PSAI also improved physical activity, body weight, sleep, perceived stress, anxiety, and depression.
Conclusion: PSAI improved total oxidant status and several patient-relevant outcomes but did not significantly affect telomere-length change. Longer, adequately powered trials with repeated biomarker assessments are require.
背景：心理压力和健康行为与氧化状态和端粒生物学有关，但来自乳腺癌幸存者多领域干预的证据仍然有限。目的：评价毕达哥拉斯自我意识干预（PSAI）对乳腺癌治疗后生物学、行为和社会心理结局的影响。方法：在这项随机对照试验中，120名妇女被随机分为8周PSAI计划组和只接受教育的对照组（各60名）；118例纳入改良意向治疗分析。主要生物学指标为血清总氧化状态和PBMC相对端粒T/S比。线性混合效应模型估计了组×时间效应、组间变化差异、95%置信区间（CI）和Hedges’g。结果：干预组总氧化状态下降更多（变化差异为-3.83 μmol/L； 95% CI为-7.03至-0.63;p = 0.020; g = -0.13）。各组间端粒长度变化无显著差异（-0.170log₂[T/S]单位；95% CI -0.554 ~ 0.214; p = 0.382; g = -0.23）。PSAI还能改善身体活动、体重、睡眠、感知压力、焦虑和抑郁。结论：PSAI改善了总氧化状态和一些患者相关的结果，但对端粒长度的变化没有显著影响。需要更长时间、充分有力的试验，并进行重复的生物标志物评估。
期刊介绍：
Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms.
Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
