Retinal microcirculatory and choroidal structural characteristics of retinal vein occlusion-related macular edema with serous retinal detachment.

IF 3.6 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Frontiers in Medicine Pub Date : 2026-10-07 eCollection Date: 2026-01-01 DOI:10.3389/fmed.2026.1941751

Xianxian Kong, Fengjiao Li, Yalin Wang, Jing Wang, Weiyan Zhou

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引用次数: 0

Abstract

Objective: To characterize retinal microcirculation and choroidal structure in treatment-naive retinal vein occlusion-related macular edema (RVO-ME) eyes with/without serous retinal detachment (SRD) using ultra-widefield swept-source OCT angiography (UWF-SS-OCTA).

Methods: This retrospective single-center study included 69 treatment-naive RVO-ME eyes (35 CRVO and 34 BRVO) classified by OCT-defined SRD. Between-group comparisons included CMT, FAZ metrics, sectoral VFD of the SCP, MCP, and DCP, SFCT, and three-dimensional choroidal metrics (CVV, CSV, CVI, and CSI). The location and extent of the occluded retinal region were also analyzed in BRVO eyes.

Results: Thirty-five CRVO and 34 BRVO eyes were included. In both subtypes, SRD eyes had shorter disease duration, greater CMT (CRVO: 795.19 ± 240.83 vs. 397.84 ± 136.56 μm; BRVO: 633.53 ± 214.39 vs. 366.47 ± 86.20 μm), and lower FAZ circularity index (CRVO: 0.64 ± 0.23 vs. 0.84 ± 0.06; BRVO: 0.80 ± 0.07 vs. 0.86 ± 0.08) than non-SRD eyes (all P < 0.05). CRVO-SRD eyes had worse BCVA and a higher proportion of ischemic eyes (13/16 vs. 6/19) than non-SRD eyes (both P < 0.05). In BRVO, occlusion location was similar between groups (superotemporal branch most common), but SRD eyes had more extensive retinal involvement (P < 0.05). BRVO-SRD eyes showed reduced retinal vascular flow density in most macular sectors. In CRVO-SRD eyes, middle capillary plexus flow density was consistently reduced across all sectors. BRVO-SRD eyes showed greater SFCT, CSV, and CVV, whereas CRVO-SRD eyes showed higher foveal CSI and lower CVI in selected sectors.

Conclusions: In treatment-naive RVO-ME eyes evaluated by UWF-SS-OCTA, SRD was associated with greater macular thickening, more irregular FAZ morphology, and more pronounced retinal microcirculatory impairment, with MCP-VFD reduction as the most consistent feature. Choroidal volume expansion in BRVO and compositional remodeling in CRVO suggest subtype-specific choroidal involvement; together, these findings support the potential value of layer-specific retinal perfusion metrics and three-dimensional choroidal parameters for imaging-based stratification.

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视网膜静脉阻塞相关性黄斑水肿伴浆液性视网膜脱离的视网膜微循环和脉络膜结构特征。

目的：应用超宽视场扫描源OCT血管造影（UWF-SS-OCTA）研究伴/不伴浆液性视网膜脱离（SRD）的初治期视网膜静脉闭塞相关性黄斑水肿（RVO-ME）患者的视网膜微循环和脉络膜结构。方法：本回顾性单中心研究纳入69只治疗初期RVO-ME眼（35只CRVO眼和34只BRVO眼），按oct定义的SRD分类。组间比较包括CMT、FAZ指标、SCP、MCP和DCP的部门VFD、SFCT和三维脉络膜指标（CVV、CSV、CVI和CSI）。分析BRVO眼视网膜区域闭塞的位置和程度。结果：包括35只CRVO眼和34只BRVO眼。在两种类型中，SRD的病程较短，CMT较大（CRVO: 795.19±240.83 vs. 397.84±136.56 μm; BRVO: 633.53±214.39 vs. 366.47±86.20 μm）， FAZ圆度指数较低(CRVO: 0.64±0.23 vs. 0.84±0.06；BRVO: 0.80±0.07 vs 0.86±0.08)(P P P P结论：在UWF-SS-OCTA评估的初治疗RVO-ME眼中，SRD与黄斑增厚，FAZ形态更不规则，视网膜微循环损伤更明显相关，MCP-VFD降低是最一致的特征。BRVO的脉络膜体积扩张和CRVO的成分重塑提示亚型特异性脉络膜受累；总之，这些发现支持层特异性视网膜灌注指标和三维脉络膜参数在基于成像的分层中的潜在价值。

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来源期刊

Frontiers in Medicine Medicine-General Medicine

CiteScore

5.10

自引率

5.10%

发文量

3710

审稿时长

12 weeks

期刊介绍： Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world