1012 – REGENERATION OF HEALTHY AND MALIGNANT HAEMATOPOIESIS: SIMILAR SIDES OF TWO VERY DIFFERENT COINS

IF 2.7 4区医学 Q2 HEMATOLOGY

Experimental hematology Pub Date : 2026-10-01 Epub Date: 2026-10-23 DOI:10.1016/j.exphem.2026.105508

Cristina Lo Celso

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Abstract

Hematopoietic stem cells (HSCs) maintain the turnover of all blood cells, involving the generation of billions and trillions of new cells every day in mice and humans. Although mostly quiescent, various stresses induce HSCs to increase proliferation and differentiate to cope with increased demand for differentiated progeny. These responses have been widely associated with loss of functional HSCs. Over the last few years, my group has focused on understanding the mechanisms leading to HSC damage during acute, severe infection, using natural rodent malaria models. In particular, we have focused on the role of the bone marrow microenvironment in mediating such damage and as a potential therapeutic target to safeguard HSC numbers and function. More recently, we started exploring mechanisms of regeneration.

Leukemia is a cancer of the blood, developing in the bone marrow and overtaking healthy hematopoiesis. Acute myeloid leukemia (AML) is the prime example of a stem cell-based cancer and is particularly difficult to treat due to the ability of leukemia stem cells (LSCs) to evade therapeutic interventions. Similar to healthy HSCs, LSCs are affected by inflammatory stimuli, and we have recently focused on the interplay between AML cells, bone marrow macrophages, and T cells to identify novel potential vulnerabilities that could be targeted to avoid relapse.

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健康和恶性造血的再生：两个截然不同的硬币的相似面

造血干细胞（hsc）维持所有血细胞的周转，涉及小鼠和人类每天产生数十亿和数万亿个新细胞。尽管大多数造血干细胞处于静止状态，但各种应激诱导造血干细胞增加增殖和分化，以应对对分化后代的需求增加。这些反应与功能性造血干细胞的丧失广泛相关。在过去的几年里，我的团队一直致力于了解急性严重感染期间导致HSC损伤的机制，使用天然啮齿动物疟疾模型。我们特别关注骨髓微环境在介导这种损伤中的作用，以及作为保护HSC数量和功能的潜在治疗靶点。最近，我们开始探索再生的机制。白血病是一种血液癌症，在骨髓中发展，超过了健康的造血功能。急性髓性白血病（AML）是基于干细胞的癌症的主要例子，由于白血病干细胞（LSCs）逃避治疗干预的能力，它特别难以治疗。与健康的造血干细胞类似，LSCs也会受到炎症刺激的影响，我们最近专注于AML细胞、骨髓巨噬细胞和T细胞之间的相互作用，以确定新的潜在脆弱性，以避免复发。造血干细胞（hsc）维持所有血细胞的周转，涉及小鼠和人类每天产生数十亿和数万亿个新细胞。尽管大多数造血干细胞处于静止状态，但各种应激诱导造血干细胞增加增殖和分化，以应对对分化后代的需求增加。这些反应与功能性造血干细胞的丧失广泛相关。在过去的几年里，我的团队一直致力于了解急性严重感染期间导致HSC损伤的机制，使用天然啮齿动物疟疾模型。我们特别关注骨髓微环境在介导这种损伤中的作用，以及作为保护HSC数量和功能的潜在治疗靶点。最近，我们开始探索再生的机制。白血病是一种血液癌症，在骨髓中发展，超过了健康的造血功能。急性髓性白血病（AML）是基于干细胞的癌症的主要例子，由于白血病干细胞（LSCs）逃避治疗干预的能力，它特别难以治疗。与健康的造血干细胞类似，LSCs也会受到炎症刺激的影响，我们最近专注于AML细胞、骨髓巨噬细胞和T细胞之间的相互作用，以确定新的潜在脆弱性，以避免复发。

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来源期刊

Experimental hematology 医学-血液学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

58 days

期刊介绍： Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.