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1010 – INFORMING THERAPEUTIC APPROACHES FOR TP53 MUTANT BLOOD CANCERS

IF 2.7 4区医学 Q2 HEMATOLOGY

Experimental hematology Pub Date : 2026-10-01 Epub Date: 2026-10-23 DOI:10.1016/j.exphem.2026.105506

Gemma Kelly, Elizabeth Lieschke, Zilu Wang, Tianwei Chen, Reet Bhandari, Andrew Kueh, Lin Tai, Marco Herold, Kate Sutherland, Andreas Strasser

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引用次数: 0

Abstract

Mutations in the tumor suppressor p53 are common in relapsed and refractory blood cancers. Despite decades of research, it is still not clear how mutant p53 contributes to sustained tumor growth. Understanding this will inform therapeutic approaches for patients with mutant p53 blood cancers. To address this, we have generated novel mouse models in which the endogenous p53 locus can be switched between different p53 states (mutant, wild-type, and knock-out) at will. We have crossed these mice to lymphoma-prone mouse models to allow a systematic assessment of the role of mutant p53 in lymphoma growth and responses to therapy.

Mutations in the tumor suppressor p53 are common in relapsed and refractory blood cancers. Despite decades of research, it is still not clear how mutant p53 contributes to sustained tumor growth. Understanding this will inform therapeutic approaches for patients with mutant p53 blood cancers. To address this, we have generated novel mouse models in which the endogenous p53 locus can be switched between different p53 states (mutant, wild-type, and knock-out) at will. We have crossed these mice to lymphoma-prone mouse models to allow a systematic assessment of the role of mutant p53 in lymphoma growth and responses to therapy.

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1010 -告知tp53突变型血癌的治疗方法

肿瘤抑制因子p53的突变在复发和难治性血癌中很常见。尽管经过了几十年的研究，人们仍然不清楚p53突变体如何促进肿瘤的持续生长。了解这一点将为突变型p53血癌患者的治疗方法提供信息。为了解决这个问题，我们建立了新的小鼠模型，其中内源性p53位点可以在不同的p53状态（突变型、野生型和敲除型）之间随意切换。我们将这些小鼠与淋巴瘤易感小鼠模型杂交，以便系统评估突变p53在淋巴瘤生长和治疗反应中的作用。肿瘤抑制因子p53的突变在复发和难治性血癌中很常见。尽管经过了几十年的研究，人们仍然不清楚p53突变体如何促进肿瘤的持续生长。了解这一点将为突变型p53血癌患者的治疗方法提供信息。为了解决这个问题，我们建立了新的小鼠模型，其中内源性p53位点可以在不同的p53状态（突变型、野生型和敲除型）之间随意切换。我们将这些小鼠与淋巴瘤易感小鼠模型杂交，以便系统评估突变p53在淋巴瘤生长和治疗反应中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental hematology

Experimental hematology 医学-血液学

CiteScore

5.30

自引率

0.00%

发文量

84

审稿时长

58 days

期刊介绍： Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.

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