1008 – CLONAL HEMATOPOIESIS IN THE HUMAN BRAIN

IF 2.7 4区医学 Q2 HEMATOLOGY

Experimental hematology Pub Date : 2026-10-01 Epub Date: 2026-10-23 DOI:10.1016/j.exphem.2026.105504

Siddhartha Jaiswal

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引用次数: 0

Abstract

The brain has been assumed to be a site where circulating blood cells are excluded from entering under normal conditions. The resident immune cells of the brain, called microglia, originate from hematopoietic precursors in the yolk sac that self-renew for life without further contribution from adult hematopoiesis, according to current dogma. Microglia, which resemble macrophages in other tissues, are important for many neurologic processes and are implicated in brain disorders, including Alzheimer’s disease. Here, I presented our recent work challenging this paradigm. I showed that hematopoietic stem cell-derived myeloid cells can colonize the human brain in aging and differentiate into bona fide microglia. I also discussed the implications of these findings for Alzheimer’s disease.

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1008 -人脑克隆造血

人们一直认为，在正常情况下，大脑是循环血液细胞无法进入的地方。根据目前的理论，大脑中的常驻免疫细胞，被称为小胶质细胞，起源于卵黄囊中的造血前体，它可以在没有成人造血进一步贡献的情况下自我更新。小胶质细胞类似于其他组织中的巨噬细胞，对许多神经过程都很重要，并与包括阿尔茨海默病在内的脑部疾病有关。在这里，我展示了我们最近挑战这种范式的工作。我展示了造血干细胞衍生的骨髓细胞可以在衰老过程中在人脑中定植并分化成真正的小胶质细胞。我还讨论了这些发现对阿尔茨海默病的影响。人们一直认为，在正常情况下，大脑是循环血液细胞无法进入的地方。根据目前的理论，大脑中的常驻免疫细胞，被称为小胶质细胞，起源于卵黄囊中的造血前体，它可以在没有成人造血进一步贡献的情况下自我更新。小胶质细胞类似于其他组织中的巨噬细胞，对许多神经过程都很重要，并与包括阿尔茨海默病在内的脑部疾病有关。在这里，我展示了我们最近挑战这种范式的工作。我展示了造血干细胞衍生的骨髓细胞可以在衰老过程中在人脑中定植并分化成真正的小胶质细胞。我还讨论了这些发现对阿尔茨海默病的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental hematology 医学-血液学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

58 days

期刊介绍： Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.