Lipid Nanoparticles at the Crossroads of Chemistry and Medicine: A Tutorial

IF 7.5 Q2 NANOSCIENCE & NANOTECHNOLOGY

ACS Nanoscience Au Pub Date : 2026-10-21 Epub Date: 2026-09-28 DOI:10.1021/acsnanoscienceau.6c00096

Myxie Tana Rogado, Audrey Wang, Sophia Zeng, Zhenghe Wang, Clemens Burda

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引用次数: 0

Abstract

Lipid nanoparticles (LNPs) have risen to the forefront of modern therapeutics by enabling the clinical success of COVID-19 mRNA vaccines. In order for them to function as drug delivery vesicles, LNPs must have scalable, tunable, and targeted nanoscale platforms whose strengths in versatility, performance, and clinical relevance are driven by key design parameters and formulation strategies. This Tutorial Review traces the historical evolution of LNPs and examines the fundamental design principles governing their structure, physicochemical properties, and biological behavior. It further highlights modern analytical characterization techniques that have advanced mechanistic understanding of LNP composition, morphology, and function as well as targeting strategies to improve LNP delivery to extrahepatic sites. Current translational challenges and emerging advances are also discussed. This Tutorial Review provides a framework for understanding the foundations, current landscape, and future directions of LNP research.

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脂质纳米颗粒在化学和医学的十字路口：教程

脂质纳米颗粒（LNPs）通过使COVID-19 mRNA疫苗取得临床成功，已经上升到现代治疗的前沿。为了使LNPs发挥药物传递囊泡的作用，它们必须具有可扩展、可调和靶向的纳米级平台，其多功能性、性能和临床相关性的优势由关键的设计参数和配方策略驱动。本教程回顾了LNPs的历史演变，并检查了控制其结构，物理化学性质和生物行为的基本设计原则。它进一步强调了现代分析表征技术，这些技术对LNP的组成、形态和功能有着先进的机制理解，以及改善LNP向肝外部位递送的靶向策略。目前的翻译挑战和新兴的进展也进行了讨论。本教程综述为理解LNP研究的基础、现状和未来方向提供了一个框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Nanoscience Au 材料科学、纳米科学-

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.