Nafisa Mahbub, Matthew Osborne, Hongmin Chen, Ayokunle Lekuti, Warren C. W. Chan
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引用次数: 0
Abstract
Widespread testing
identifies infectious diseases early and reduces
silent transmission. The large size of devices for testing limits
their use in the field. We developed a portable device that miniaturizes
nucleic acid testing: the QMini. The QMini simplified a fluidic module
using direct connections between pumps and reaction chambers. It shielded
an optical module from ambient light with a 3D-printed enclosure.
We applied the QMini to detect synthetic nucleic acid sequences of
respiratory syncytial virus B, SARS-CoV-2, and influenza A with a
bead-based assay using quantum dot barcodes. The QMini detected 500
copies of respiratory syncytial virus B, 500 copies of SARS-CoV-2,
and 1,000 copies of influenza A. We observed limited cross-reactivity
in the QMini with six nontarget viral nucleic acid sequences. The
QMini advances the portability of nucleic acid testing using quantum
dot barcodes through device miniaturization.
期刊介绍：
ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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